Single breathhold, three-dimensional measurement of left atrial volume and function using sparse CINE CMR imaging with iterative reconstruction

Methods A highly accelerated prototype cine sequence with sparse sampling and Iterative Reconstruction (sCINE-IR) was used in phantoms and patients to acquire 5 cine slices (2 long axis, LAX and 3 short axis, SAX) through the LA during a single breathhold yielding a spatial/temporal resolution of 1.5mm/30ms (1.5T Aera, Siemens AG, Germany). The LA volumes were reconstructed from these 5 slices using a non-model based method (Bermano A, ACM trans Graph 2011). As a reference in patients, a self-navigated high-resolution whole-heart 3D dataset (3D-HR) was acquired during mid-diastole, from which the LA volume was segmented. Phantom study. Five LA phantoms made of solanum tuberosum L of known volume (water displacement method) and of different shapes were imaged with both 3D-HR and CS in various slice orientations and the calculated volumes were compared. Patients study. Three patients were scanned with both 3D-HR and sCINE-IR. The volumes obtained with 3D-HR and with sCINE-IR during the corresponding mid-diastolic frame were compared using Bland-Altman method and linear regression.